Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-04-09
1977-12-06
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260268PC, 26029356, 2603268, 260631R, 26034811, 260563P, 4242484, 424250, 424267, 424274, 544154, A61K 3113, C07C 8740
Patent
active
040617742
ABSTRACT:
Novel 2-substituted-1-methylamino adamantanes of formula: ##STR1## where X is hydroxyl or halogeno, and R.sup.1, R.sup.2 and R.sup.3 are hydrogen or C.sub.1-4 alkyl or R.sup.2 and R.sup.3 together with the nitrogen form a heterocyclic ring, having anti-Parkinsonian activity, pharmaceutical formulations containing the active adamantanes and novel 4-protoadamantane spiro oxirane and 1,2-difunctionalized intermediates useful in the preparation of the final products of the invention.
REFERENCES:
patent: 3859352 (1975-01-01), Szinai et al.
Tabushi et al., Chemical Abstracts, vol. 68 (1968), abstract 86,625w, p. 8333.
E. I. Du Pont de Nemours & Co., Chemical Abstracts, vol. 63, p. 516c (1965).
E. I. Du Pont de Nemours & Co., Chemical Abstracts, vol. 75, p. 140372w, (1971).
Chakrabarti Jiban Kumar
Hotten Terrence Michael
Tupper David Edward
Daus Donald G.
Lilly Industries Limited
Page Kathleen R. S.
Smith Everet F.
Wheeler David E.
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