N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]amide congeners as musc

Details N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]amide congeners as musc N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]amide congeners as musc

1992-04-30

1993-12-28

Waddell, Frederick E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514428, C07D20708, C07D20746, A61K 3140

Patent

active

052741214

ABSTRACT:
Compounds, which are muscarinic agents, having the formula ##STR1## wherein Am is --N(R).sub.a).sub.2, --N(R.sub.a).sub.3.sup.+ I.sup.-, --N (CH.sub.2).sub.n', or ##STR2## n' is an integer from 2 to 7 and R.sub.a is an alkyl having 1 to 4 carbon atoms, and each R.sub.a may be the same or different wherein the other substituents are defined hereinbelow.

REFERENCES:
patent: 3354178 (1967-11-01), Dickinson
patent: 4065471 (1977-12-01), Dickinson
CA vol. 108, No. 3, abstract 16138K of Ringdahl, et al., J. Pharmacol. Exp. Ther. 1987, 242(2).
Bradbury, et al., "Design of Novel Muscarinic Agents", Journal of Medicinal Chemistry, Feb. 1990, pp. 741-748.

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