Phosphono substituted tetrazole derivatives

Details Phosphono substituted tetrazole derivatives Phosphono substituted tetrazole derivatives

Filed on

1992-09-03

Date issued

1993-12-28

Examiner

Lee, Mary C.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514382, 514340, 548119, 546 22, C07D25704, A01N 5724

Type

Patent

Status

active

Patent number

052739902

Description

ABSTRACT:
The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula I ##STR1## and tautomers thereof wherein R.sub.1 is aryl or biaryl; n is zero, 1 or 2 pharmaceutically acceptable mono- or di-ester derivatives thereof in which one or both of the acidic hydroxy groups of the phosphono functional group are esterified in form of a pharmaceutically acceptable mono- or di-ester; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds and for the preparation of intermediates; and methods of treating disorders in mammals which are responsive to the inhibition of neutral endopeptidases by administration of said compounds to mammals in need of such treatment.

REFERENCES:
patent: 4939261 (1990-07-01), Ksander
patent: 5021430 (1991-06-01), Ksander
patent: 5155100 (1992-10-01), Erion et al.
FEBS Letters, vol. 212, No. 1, 83-86, Feb. 1987, Kojro et al.
J. Org. Chem. 1991, 56, 2395-2400 Duncia et al.
Tetrahedron Letters, 491-494 (1979), Faubl.
Roczniki Chemie Ann. Soc. Chem. Polonorum, 45, 967 (1971), Grzonka et al.
Research Communications in Chemical Pathology & Pharmacology, vol. 52, No. 1, (1986) Weiss et al.
Medicinal Research Reviews, vol. 5, No. 4, 483-531 (1985) Weiss et al.
J. Org. Chem. 1987, 52, 2051-2059 Yu et al.
Tetrahedron Letters, vol. 21, pp. 2689-2692 Yaouanc et al. (1980).
Tetrahedron Letters, vol. 31, No. 12, pp. 1755-1758, 1990 Anderson et al.

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