Inorganic and organic composition for treatment of bone lesions

Details Inorganic and organic composition for treatment of bone lesions Inorganic and organic composition for treatment of bone lesions

1988-12-07

1993-12-28

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514802, 424602, 530356, 128DIG8, 607 94, A61K 3702, A61K 3342

Patent

active

052739643

ABSTRACT:
A method for the treatment of bone lesions or bone deficiencies in a living mammal comprising administering a composition comprising an inorganic phase and an organic phase wherein the inorganic phase comprises a porous particulate TCP ceramic or a nonporous or microporous particulate HAP ceramic or a mixture of porous particulate TCP ceramic and nonporous or microporous particulate HAP ceramic, wherein the organic phase comprises a purified hydrated collagen product which is mixed with and forms a continuous or substantially continuous surface coating over said inorganic phase(s) and a hydrated collagen-demineralized bone product which is mixed with and forms a substantially continuous surface coating over said purified hydrated collagen product surface coating or the organic phase comprises a hydrated collagen-demineralized bone product which is mixed with and forms a continuous or substantially continuous surface coating over said inorganic phase and a purified hydrated collagen product which is mixed with and forms a continuous or substantially continuous surface coating over said hydrated collagen-demineralized bone product surface coating. The composition may be administered at surgical reconstruction or delivered to the lesion site by syringe.

REFERENCES:
patent: 3649347 (1972-03-01), Battista
patent: 4097935 (1978-07-01), Jarcho
patent: 4440750 (1984-04-01), Glowacki et al.

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