Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-09-22
1993-12-28
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 21, A61K 3736
Patent
active
052739619
ABSTRACT:
A method is disclosed for the prophylactic treatment of mammals at risk for acute renal failure, whether due to renal ischemia or nephrotoxic damage. This method involves administering to the mammal, before or at the time that the acute renal failure is expected to occur or is occurring, an effective amount of IGF-I. Preferably, the IGF-I is native-sequence, mature human IGF-I.
REFERENCES:
patent: 5106832 (1992-04-01), Froesch et al.
patent: 5126324 (1992-06-01), Clark
Gershberg, J. Clin. Endocr. and Metab., 20: 1107-1119 (1960), "Metabolic & Renotropic Effects of hGH in Disease".
Turner et al., in Proc. of 2nd Intl. Symp. on IGF-I/Somatomedins, Jan. 12-16, 1991, S.F., CA, Spencer, Ed., "Evidence that the Inhibition of Osteoblast Activity . . . ", Elsevier Science Publ. Co (1991) pp. 143-153.
Norman et al., Clin. Science, 78:445-450 (1990).
Han et al., Science, 236: 193-197 (1987).
Gershberg et al., J. Clin. Endocr. & Metab., 17:377-385 (1957).
White et al., J. Clin. Endocr. & Metab., 157:47-51 (1949).
Beck et al., Metab., 13(10 [2]: 1108-1134 (1964).
Hirschberg et al., Kidney Intl., 35: 865-870 (1989).
Haffner et al., Clin. Nephrology, 32(12): 266-269 (1989).
Reiss et al., Kidney Itnl., 37(1): 492 (1990).
Andersson & Jennische, Acta. Physiol. Scand., 132:453-457 (1988).
McConaghey & Dehnel, J. Endocr., 52:587-588 (1972).
Parving et al., Acta Endocr., 89:796-800 (1978).
Corvilain et al., J. Clin. Invest., 41(6):1230-1235 (1962).
Corvilain et al., J. Clin. Invest., 43(8):1608-1612 (1964).
Lajara et al., Am. J. Physiol., 257:F252-F261 (1989).
Koch et al., J. Pediatr., 115:365-371 (1989).
Coimbra et al., Am. J. Physiol., 259:F438-F443 (1990).
Humes et al., J. Clin. Invest., 84:1757-1761 (1989).
Goler et al., Acta Endocr., 121:101-106 (1989).
Hirschberg & Kopple, J. Clin. Invest., 83:326-330 (1989).
Caverzasio et al., Endocr., 127(1):453-459 (1990).
Guler et al, PNAS USA, 86:2868-2872 (1989).
Arnqvist et al., Am. J. Physiol., 254:C411-C414 (1988).
Conti et al., Am. J. Physiol., 255:F1214-F1219 (1988).
Pillion et al., Am. J. Physiol., 255:E504-E512 (1988).
Hammerman & Gavin, Am. J. Physiol., 251:E32-E41 (1986).
Rogers & Hammerman, PNAS USA, 86:6363-6366 (1989).
Rogers et al., Am. J. Physiol., 259:F474-F479 (1990).
Han et al., Pediat. Res., 22(3):245-249 (1987).
Fagin & Melmed, Endocr., 120(2):718-724 (1987).
Murphy et al., Endocr., 121(2):684-691 (1987).
D'ercole et al., PNAS USA, 81:935-939 (1984).
Stiles et al., Endocr., 117(6):2397-2401 (1985).
Flysbjerg et al., Modern Concepts of Insulin-Like Growth Factors, Spencer, Ed., Elsevier Publishing, NY, pp. 207-217 (1991).
Lemmey et al., Am. J. Physiol., 260:E213-E219 (1991).
Van Bool-Offers et al., Ped. Res., 20(9):825-827 (1986).
Philipps et al., Ped. Res., 23(3):298-305 (1988).
Skottner et al., Endocr., 124(5):2519-2526 (1989).
Scheiwiller et al, Nature, 323:169-171 (1986).
Skottner et al., J. Endocr., 112:123-132 (1987).
Guler et al., PNAS USA, 85:4889-4893 (1988).
Rogers et al., Am. J. Physiol., 259:F474-F479 (1990).
Mulroney & Haramati, 73rd Ann. Mtg., Endocrine Society, 6-19/22-91, p. 141.
Miller et al., Am. J. Physiol., 259:F747-F751 (1990).
Froesch et al, Tem, 1(5):254-260 (1990).
Welbourne & Cronin, Am. J. Physiol., 260:R1036-R1042 (1991).
Hirschberg et al., J. Clin. Inv., 87:1200-1206 (1991).
Quigley & Boum, J. Clin. Invest., 88:368-374 (1991).
Hammerman, Am. J. Physiol., 257:F508-F514 (1989).
Genentech Inc.
Hasak Janet E.
Schain Howard E.
Touzeau P. Lynn
LandOfFree
Method of prophylaxis of acute renal failure does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of prophylaxis of acute renal failure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of prophylaxis of acute renal failure will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1542700