Stabilized liquid coenzyme compositions for diagnostic determina

Details Stabilized liquid coenzyme compositions for diagnostic determina Stabilized liquid coenzyme compositions for diagnostic determina

1977-03-09

1982-01-12

Naff, David M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 14, 435 16, 435 17, 435 26, 435183, C12Q 100, C12Q 132, C12Q 148, C12N 900

Patent

active

043106242

ABSTRACT:
Labile coenzymes, such as reduced nicotinamide-adenide dinucleotide (NADH.sub.2), used in biological diagnostic determinations are stabilized by forming a composition of the coenzyme with an organic solvent such as 1,2 propanediol in the presence of at least 1% by volume of a solid, inert hygroscopic agent such as 10% by volume of a molecular sieve material. After stabilization, the inert hygroscopic agent can be removed without materially affecting stabilization of the composition. The stabilized composition shows excellent shelf life and a container in which the composition is stored may be repeatedly opened for use without degradation of the labile coenzymes such as the labile NADH.sub.2.

REFERENCES:
patent: 2882244 (1959-04-01), Milton
patent: 3776900 (1973-12-01), Hammer
patent: 3819487 (1974-06-01), Bernt et al.
George et al., Biochim. Biophys. Acta. 191 (1969), pp. 466-468.

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