Process for the preparation of bis-indole alkaloids and acid-add

Details Process for the preparation of bis-indole alkaloids and acid-add Process for the preparation of bis-indole alkaloids and acid-add

1980-04-08

1982-01-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602444, A61K 31475, C07D51904

Patent

active

043105289

ABSTRACT:
A process for the preparation of diindole-alkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --O--R group wherein R is lower alkyl, having antitumor properties. The starting materials are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. and preferably below -45.degree. C. where the new compounds are to be produced, a lower alkanol being present in this case.

REFERENCES:
patent: 3392173 (1968-07-01), Hargrove
patent: 3899493 (1975-08-01), Jovanovics et al.
patent: 4110330 (1978-08-01), Barnett et al.
patent: 4189432 (1980-02-01), Jovanovics et al.

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