Pharmaceutical compositions of cisplatin

Details Pharmaceutical compositions of cisplatin Pharmaceutical compositions of cisplatin

1979-10-01

1982-01-12

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Anti-idiotypic

A61K 3324

Patent

active

043105157

ABSTRACT:
A stable, sterile aqueous solution of cisplatin in a sealed container such as an ampul or vial in unit dosage form suitable for intravenous administration to man is provided which has a concentration of cisplatin between about 0.1 and about 1.0 mgm./ml. and a pH in the range of 2.0 to 3.0 or preferably about 2.5. It can also contain sodium chloride and mannitol.

REFERENCES:
Handelman et al., Cancer Therapy Evaluation Program, Div. of Cancer Treatment, National Cancer Ins. (Aug. 1974) pp. 1-5 and 31-32.
Rossoe et al., Cancer 30 pp. 1451-1456 (1972).
Rozencweig et al., Annals of Internal Med., 86 pp. 803-812 (1977).

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