Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1979-11-08
1982-01-12
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
252316, 252319, 424 9, 424 35, A61K 4900, A61K 4300, B01J 1300
Patent
active
043105050
ABSTRACT:
Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 1-thio-.alpha.-D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.beta.-D-galactopyranoside; or 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.alpha.-D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.
REFERENCES:
patent: 3522346 (1970-07-01), Chang
patent: 3663685 (1972-05-01), Evans
patent: 3663687 (1972-05-01), Evans
patent: 3683066 (1972-08-01), Ascanio et al.
patent: 3932657 (1976-01-01), Rahman
patent: 3937668 (1976-02-01), Zolle
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4086330 (1978-04-01), Petkao et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4115536 (1978-09-01), Rothman et al.
patent: 4193983 (1980-03-01), Ullman et al.
Gregoriadis, N. Eng. J. Med., vol. 295, Sep. 23, 1976, pp. 704-710.
Baldeschwieler John D.
Gamble Ronald C.
Mauk Marcia R.
Ponpipom Mitree M.
Shen Tsung-Ying
California Institute of Technology
Mueth Joseph E.
Nucker Christine M.
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