Thio etianic acid derivatives

Details Thio etianic acid derivatives Thio etianic acid derivatives

1980-11-07

1982-01-12

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

A61K 3156, C07J 900

Patent

active

043104665

ABSTRACT:
Certain 16.beta.-methyl-3-oxoandrost-4-ene and 16.beta.-methyl-3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 6.alpha.-position with fluoro or chloro; optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a .beta.-hydroxy or a .beta.-chloro (the latter only when there is a 9.alpha.-chloro); and substituted with 17.alpha.-hydroxy (or an ester thereof).

REFERENCES:
patent: 4093721 (1978-06-01), Phillipps et al.
patent: 4188385 (1980-02-01), Edwards
patent: 4198403 (1980-04-01), Alvarez

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