Polymer-bound nitric oxide/nucleophile adduct compositions, phar

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

526311, 514611, 528422, C08K 522, A01N 3326, A61K 31785, C08F 830

Patent

active

054059194

ABSTRACT:
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

REFERENCES:
patent: 3153094 (1964-10-01), Reilly
patent: 4265714 (1981-05-01), Nolan et al.
patent: 4482533 (1984-11-01), Keith
patent: 4638079 (1987-01-01), Inskip et al.
patent: 4708854 (1987-11-01), Grinstead
patent: 4921683 (1990-05-01), Bedell
patent: 4952289 (1990-08-01), Ciccone et al.
patent: 4954526 (1990-09-01), Keefer
patent: 4985471 (1991-01-01), Ohta et al.
patent: 5039705 (1992-08-01), Keefer et al.
patent: 5087631 (1992-02-01), Shaffer et al.
patent: 5087671 (1992-02-01), Loeppky et al.
patent: 5094815 (1992-03-01), Conboy et al.
patent: 5155137 (1992-10-01), Keefer et al.
Article by Maragos, et al., Complexes of NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects, J. Med. Chem., 34, 3242-3247.
Article by Myers, et al., Vasorelaxant Properties of the Endothelium-Derived Relaxing Factor more closely Resemble S-Nitrosocystein Than Nitric Oxide, Nature, vol. 345.
Article by Ignarro, Endothelium-Derived Nitric Oxide: Actions and Properties, The FASEB Journal, vol. 3, Jan.
Article by DeFeudis, Endothelium-Dependent Vasorelaxation--A New Basis for Developing Cardiovascular Drugs, Drugs of Today, vol. 24, No. 2, pp. 103-115.
Article by Palmer, et al., Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor, Nature, vol. 327 11, Jun.
Article by Kruszyna, et al., Red Blood Cells Generate Nitric Oxide from Directly Acting, Nitrogenous Vasodilators, Toxicol. Appl. Pharmacol., 91, 429-438.
Article by Trissel, Intravenous Infusion Solutions, Handbook on Injectable Drugs, Fourth Addition.
Article by Furchgott, The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs,Ann. Rev. Pharmacol, Toxicol, 24:175-97.
Article by DeLuca, et al., Parenteral Drug-Delivery Systems, Pharmaceutics and Pharmacy Practice.
Article by Hansen, et al., N-Nitrosation of Secondary Amines by Nitric Oxide Via the `Drago Complex`, IARC Sci., Publ. No. 41 pp. 21-29.
Article by Ignarro, et al., Mechanism of Vascular Smooth Muscle Relaxation by Organic Nitrates, Nitrites, Nitroprusside and Nitric Oxide: Evidence from the Involvement of S-Nitrosothiols as Active Intermediates, J. Pharmacol. Exp. Ther., 218, 739-749.
Article by Lutz, et al., Isolation of Trioxodinitrato (II) Complexes of Some First Row Transition Metal Ions, J.C.S. Chem. Comm.
Article by Nakanishi, et al., Participation of Hydrocarbons in the Photodimerization of 3, 4-Dichlorocinnamic Acid, J.C.S. Chem. Comm.
Article by Longhi, et al., Metal-Containing Compounds of the Anion (C.sub.2 H.sub.5).sub.2 NN.sub.2 O.sub.2 --, Insrg. Chem., vol. 2 Feb.
Article by Drago, Reactions of Nitrogen (II) Oxide, Advances in Chemistry Series, No. 36.
Article by Drago, et al., The Reaction of Nitrogen (II) Oxide with Various Primary and Secondary Amines, Journal of Amer. Chem. Soc. vol. 83, Apr. 20.
Article by Garg, et al., Nitric Oxide-Generating Vasodilators Inhibit Mitogenesis and Proliferation of Balb/C3T3 Fibroblasts By A Cyclic GMP-Independent Mechanism, Biochem. and Biophys. Res. Comm., 171, 474-479.
Article by Hibbs, Jr., et al., Nitric Oxide: A Cytotoxic Activated Macrophage Effector Molecule, Biochem. and Biophys. Res. Comm., 157, 87-94.
Article by Holford, et al., Understanding the Dose-Effect Relationship: Clinical Application of Pharmacokinetic-Pharmacodynamic Models, Clinical Pharmacokinetics, 6, 429-453.
Article by Ignarro, Nitric Oxide. A Novel Signal Transduction Mechanism for Transcellular Communication, Hypertension (Dallas), 16, 477-483.
Article by Ignarro, Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide, Annu. Rev. Pharmcol. Toxicol., 30, 535-560.
Article by Ignarro, et al., The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation, Annu. Rev. Pharmacol. Toxicol., 25, 171-191.
Article by Kuhn, et al., Endothelium-Dependent Vasodilatation in Human Epicardial Coronary Arteries: Effect of Prolonged Exposure to Glycerol Trinitrate or SIN-1, J. Cardiovasc. Pharmacol., 14 (Suppl. 11), S47-S54.
Marletta, et al., Unraveling the Biological Significance of Nitric Oxide, BioFactors, 2, 219-225.
Smith, et al., Nitroprusside: A Potpourri of Biologically Reactive Intermediates, Biological Reactive Intermediates IV. Molecular and Cellular Effects and Their Impact on Human Health (Witmer, et al., eds.), Advances in Experimental Medicine and Biology, vol. 283 (Plenum Press, pp. 365-369).
Stuehr, et al., Nitric Oxide: A Macrophage Product Responsible for Cytostasis and Respiratory Inhibition in Tumor Target Cells, J. Exp. Med., 169, 1543-1555.
WHO Task Group on Environmental Health Criteria for Oxides of Nitrogen, Oxides of Nitrogen, Environmental Health Criteria 4 (World Health Organization: Geneva).
Article by Wilcox, et al., Effect of Cyanide on the Reaction of Nitroprusside with Hemoglobin: Relevance to Cyanide Interference With the Biological Activity of Nitroprusside, Chem. Res. Toxicol., 3, 71-76.
Article by Stamler, et al., S-Nitrosylation of Proteins With Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds, Proc. Natl. Acad. Sci., USA, vol. 89, pp. 444-448, Jan.
Article by Smith, et al., Complex Contractile Patterns in Canine Colon Produced by Spontaneous Release of Nitric Oxide, Gastroenterology, vol. 102, No. 4 Part 2, Apr.
Article by Jones, Metastable Polymers of the Nitrogen Oxides. 1. Open Chain Nitric Oxide Analogues of Polythlazyl: A MNDO/AM1 Study, J. Phys. Chem., 95, 2588-2595.
Article by Middleton, et al., Further Studies on the Interaction of Nitric Oxide With Transition-Metal Alkyls, J.C.S. Dalton, pp. 1898-1905, Feb. 6.
Article by Bonakdar, et al., Continuous-Flow Performance of Carbon Electrodes Modified With Immobilized Fe(II)/Fe(III) Centers, Calanta, vol. 36, No. 1/2, pp. 219-225.
Article by Park, et al., Controlled Protein Release from Polyethyleneimine-Coated Poly (L-lactic Acid)/Pluronic Blend Matrices, Pharmaceutical Research, vol. 9, No. 1.
Uber Reaktionen und Eigenschaften des Stickoxyds und seiner Verbindungen, II. Mitteil: Zur Kenntnis der Salze Der stickoxyd-schwefligen Saure, Heinz Gehlen, Aus D. Chem. Institut D. Universitat Konigsberg I. PR., Eingegaugen am 1. Juni.
Der Raman-Effekt als Grundlage einer organischen Spektralanalyse (I. Mitteil.), Birchkenbach, et al., Aus D. Chem. Institut D. Betgakademie Clausthal, Eingegaugen am 9, Juni.
Synthesis of 1-Alkoxy-3,3-Dialkyltriazene 2-Oxides from Alkoxyamines and Nitrosoamines, Artsybasheva, et al., A. A. Zhdanov Leningrad State University, Translated from Zhurhal Organicheskoi Khimii, vol. 28, No. 6, pp. 1168-1173, Jun., Original article submitted May 28, 1986.
Jones, "Metastable Polymers of the Nitrogen Oxides. 2. Open-Chain Polymers of the Nitric Oxide Dimers and of Nitrous Oxide: A MNDO/AM1 Study," J. Phys. Chem., 96, 594-603 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polymer-bound nitric oxide/nucleophile adduct compositions, phar does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymer-bound nitric oxide/nucleophile adduct compositions, phar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymer-bound nitric oxide/nucleophile adduct compositions, phar will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1539155

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.