Angiotensin II receptor blocking 2,3,6 substituted quinazolinone

Details Angiotensin II receptor blocking 2,3,6 substituted quinazolinone Angiotensin II receptor blocking 2,3,6 substituted quinazolinone

1993-10-29

1995-04-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544284, 544287, A61K 31505, C07D40310, C07D23991

Patent

active

054058490

ABSTRACT:
Novel quinazolinone compounds of the formula: ##STR1## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to alleviate angiotensin induced hypertension and treat congestive heart failure in mammals.

REFERENCES:
patent: 5240928 (1993-08-01), Allen
Chio et al, European J. Pharmacology, 157 (1988) 13-21.

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