Polypeptides related to the pre-acetylcholine receptor-.alpha. o

Details Polypeptides related to the pre-acetylcholine receptor-.alpha. o Polypeptides related to the pre-acetylcholine receptor-.alpha. o

1983-08-16

1985-05-21

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045185271

ABSTRACT:
Polypeptides having partial or complete amino acid sequences related to the pre-acetylcholine receptor-.alpha. of the electric organ Torpedo californica are disclosed. These polypeptides having AChR antigenic properties are useful for the production and purification of antibodies to the acetylcholine receptor (AChR) as well as for the diagnosis of myastenia gravis (MG).

REFERENCES:
Proc. Nat'l Acad. Sci., vol. 75, (1978), 769-773.
Biochemistry, vol. 18, (1979), 4470-4480.
Lindstrom and Lennon, "Experimental Autoimmune Myasthenia Gravis and Myasthenia Gravis: Biochemical and Immunochemical Aspects", Annals New York Academy of Sciences, pp. 254-274.
Almon et al., "Serum Globulin in Myasthenia Gravis: Inhibition of .alpha.-Bungarotoxin Binding to Acetylcholine Receptors", Science, vol. 186, Oct. 1974, pp. 55-57.
Patrick and Lindstrom, "Autoimmune Response to Acetylcholine Receptor", Science, vol. 180, May 1973, pp. 871-872.
Fambrough et al., "Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors", Science, vol. 182, Oct. 1973, pp. 293-295.

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