Antihyperlipidemic cinnamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514346, 514352, 514354, 514355, 514356, 514357, 546226, 546291, 546309, 546316, 546322, 546323, 546326, 546337, A61K 3144, C07D21370, C07D21379, C07D21381

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active

052946240

ABSTRACT:
Novel cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4616086 (1986-10-01), Witte et al.
"Studies on Styrene Derivatives. II. Synthesis and Anti-Inflammatory Activity of 3,5-Di-tert-butyl-4-hydroxystyrenes", Ikuo Katsumi, et al, Chemical and Pharmaceutical Bulletin., vol. 34, No. 4, Apr. 1, 1986, Tokyo JP, pp. 1619-1627.
"3,5-di-tert-butyl-4-hydroxycinnamamide derivatives as cardiotonics and their preparation", Fuse Yoshihide, et al., Chemical Abstracts, vol. 110, No. 1, Jan. 2, 1989, p. 719; col. 1; ref. No. 7874M, Columbus, Ohio, USA.
"Preparation of 3,5-di-tert-butyl-4-hydroxycinnamamide derivatives as anti-inflammatory", Ooe Takanori, et al., Chemical Abstracts, vol. 109, No. 21, Nov. 21, 1988, p. 675; col 1; ref. No. 190072E, Columbus, Ohio, USA.
"3,5-Di-tert-butyl-4-hydroxycinnnamamide derivatives containing heterocycles", Chemical Abstracts, vol. 105, No. 13, Sep. 29, 1986, p. 682; col. 2; ref. No. 115081F, Columbus, Ohio, USA.
"Preparation of quinolin-2-one derivatives as psychotropics, antihypertensives, antiinflammatories", Chemical Abstracts, vol. 111, No. 13, Sep. 25, 1989, p. 651; col. 2; ref. No. 115059D, Columbus, Ohio, USA.

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