Thieno tetrahydropyridines useful as class III antiarrhythmic ag

Details Thieno tetrahydropyridines useful as class III antiarrhythmic ag Thieno tetrahydropyridines useful as class III antiarrhythmic ag

1992-10-07

1994-03-15

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546114, A61K 31435, C07D49504

Patent

active

052946215

ABSTRACT:
This invention relates to thieno tetrahydropyridine and isoquinoline derivative compounds which are useful as antiarrhythmic agents, pharmaceutical compositions comprising such compounds, novel intermediates for their preparation and their methods of use. More particularly these thieno tetrahydropyridine and isoquinoline derivative compounds have been demonstrated to increase the effective refractory period (ERP) of isolated perfused cardiac tissue in vitro.

REFERENCES:
patent: 4051141 (1977-09-01), Castaigne
patent: 4075340 (1978-02-01), Maffrand
patent: 4681888 (1987-07-01), Esanu

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