Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-29
1994-03-15
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514258, 514278, 514317, 514323, 546183, 546201, 546 16, 546192, 546240, 546236, 544282, C07D23970, C07D22100, A61K 3144, A61K 31505
Patent
active
052946193
ABSTRACT:
A series of novel N-alkyl or oxyalkyl arylpiperidine derivatives have been prepared, including their pharmaceutically acceptable acid addition salts, wherein the N-alkyl or oxyalkyl side chain is further substituted by certain aryl or heterocyclic ring groups. These particular compounds are useful in therapy as neuroleptic agents for the control of various psychotic disorders. Typical and preferred member compounds include 4-{{4-{2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}phenyl}}thiazole-2-amine , 4-{{4-{4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}phenyl}}thiazole-2-a mine, 3-{4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}-1,8,8-trimethyl-3-azabic yclo[3.2.1]octane-2,4-dione, 5-{2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}oxindole and 3-{2-[4-(1-naphthyl)-1-piperidinyl]ethyl}-2-methyl-4H-pyrido[1,2-a]pyrimid ine-4-one, respectively. Methods for preparing all these compounds from known starting materials are provided.
REFERENCES:
patent: 3573310 (1971-03-01), Van Dyke et al.
patent: 4623728 (1986-11-01), Sarges
Maryanoff et al., J. Org. Chem. 48(25) (1983) pp. 5074-5080 and 5080-M1 through 5080-M12.
Hacksell et al., J. Med. Chem., 24 1475-1482 (1981).
Rehse et al., Arc. Pharm. 312 670-681 (1979).
Ginsburg Paul H.
Grumblin Matthew V.
Pfizer Inc.
Richardson Peter C.
Shah Mukund J.
LandOfFree
Arylpiperidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Arylpiperidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylpiperidine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1536232