Cyclic nitrones, pharmaceutical compositions thereof and their u

Details Cyclic nitrones, pharmaceutical compositions thereof and their u Cyclic nitrones, pharmaceutical compositions thereof and their u

1992-08-05

1994-03-08

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514213, 514217, 514307, 514309, 514416, 540543, 540593, 546 18, 546150, 548411, 548470, A61K 3147, C07D21708, C07D22120

Patent

active

052927466

ABSTRACT:
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.

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patent: 5025032 (1991-06-01), Carney et al.
Jonsson, et al., "Chemical Abstracts", vol. 78, 1973, Col. 159460g.
Patent Abstracts of Japan vol. 12, No. 283 (C-518) (3130) Aug. 3, 1988 & JP-A-63 063 851 (Univ. Osaka) Mar. 22, 1988.
Interleukin-1 and Interleukin-1 Antagonism, Blood, vol. 77, No. 8 (Apr. 15), 1991: pp. 1627-1652, Charles A. Dinarello.
An Unanesthetized-Gerbil Model of Cerebral Ischemia-induced Behavioral Changes, Journal of Pharmacological Methods 14, 137-146 (1985) Chandler, et al.
A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines, J. Org. Chem. 1991, 56, 6034-6038, Larsen et al.
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-.alpha.-phenylnitrone, Proc. Natl. Acad. Sci. USA vol. 88, pp. 3633--3636, May 1991 Neurobiology, Carney et al.
Tungstate-Catalyzed Oxidation of Secondary Amines to Nitrones, .alpha.-Substitution of Secondary Amines via Nitrones, Murahashi, et al; J. Org. Chem. 1990, 55, 11736-1744.

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