Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine de

Details Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine de Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine de

1992-02-04

1994-03-08

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546340, 546346, C07D21170, A61K 3144, A61K 31445

Patent

active

052927458

ABSTRACT:
The invention concerns the use of a compound of formula (I) ##STR1## wherein R and R.sub.1, each independently, represent a hydrogen atom or a methyl group, and its pharmaceutically acceptable acid addition salts, as free radical scavengers. The pharmaceutical compositions containing these compounds may be employed in the treatment and/or prevention of pathological processes involving cell damage due to the formation of free radicals.
The invention also concerns the compounds of formula (I) wherein at least one of R and R.sub.1 is methyl, which are new compounds, as well as the process for the preparation thereof and the pharmaceutical compositions containing them.

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patent: 5109005 (1992-04-01), Croci et al.
Woodruff et al., Annals of the Rheumatic Diseases, 45, 1986, 608-611.
Cross et al., Annals of Internal Medicine, 107, 4, 1987, 526-545.

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