(17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t

Details (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t

1974-12-23

1976-07-06

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, 26039745, 26023957, C07J 500

Patent

active

039681327

ABSTRACT:
(17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones are prepared by the reaction of a 17-oxo androstane, wherein all other ketones are blocked, with a cyclopropylarylsulfide or with a cyclopropylarylsulfonium salt having a non-nucleophilic anion, in an organic solvent together with a strong base, followed by reaction in situ of the intermediate thereby formed with aqueous acid or water.
Some (17R)-spiro-[androstan-17,1'-cyclobutan]-2'-ones are useful as intermediates in preparing (17R)-spiro-[3-oxo-4-androstene-17,1'-cyclobutan]-2'-ones which are aldosterone antagonists. Additionally, (17R)-spiro-[androstane-17,1'-cyclobutan]-2'-ones are useful as intermediates in preparing known 17.alpha.-pregnane-21,17.beta.-carbolactones, valuable aldosterone blocking agents.

REFERENCES:
patent: 3657288 (1972-04-01), Wiechert

Affiliated with

Also associated with

Rating

(17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1533205