Process for the preparation of optically active 3-quinuclidinol

Details Process for the preparation of optically active 3-quinuclidinol Process for the preparation of optically active 3-quinuclidinol

1997-01-16

1998-04-28

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45300, C07D45302

Patent

active

057446067

ABSTRACT:
Optically active 3-quinuclidinol is obtained by the asymmetric hydrogenation of 3-quinuclidinone, its Lewis acid adducts or its tertiary or quaternary salts, for example, 1-(diphenylmethyl)-3-oxoquinuclidinium bromide. Rhodium/chiral diphosphine complexes with a metallocene structure are preferably used as catalysts. Optically active 3-quinuclidinol is a synthetic building block for pharmaceutical active substances (M.sub.1 receptor agonists).

REFERENCES:
Chemical Abstracts, vol. 92, No. 5, Feb. 4, 1980, Columbus, Ohio, U.S., Abstract No. 41726.

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