Process for the manufacture of 1-hydroxy-2-pyridones

Details Process for the manufacture of 1-hydroxy-2-pyridones Process for the manufacture of 1-hydroxy-2-pyridones

1974-08-30

1976-07-06

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21302

Patent

active

039681181

ABSTRACT:
New 1-hydroxy-2-pyridones of the general formula ##SPC1##
In which R.sub.1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or .alpha.-furyl, all of which may be substituted by halogen, and R.sub.2 to R.sub.4 are hydrogen or lower alkyl, or two adjacent substituents together form a trimethylene or tetramethylene chain, and in which R.sub.1 to R.sub.4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated .delta.-keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization.

REFERENCES:
patent: 2540218 (1951-02-01), Shaw
patent: 2748142 (1956-05-01), Clauson-Kaas et al.
patent: 3227708 (1966-01-01), Yale et al.
patent: 3269904 (1966-08-01), Bernstein et al.
patent: 3883545 (1975-05-01), Lohaus et al.
Adams et al., J. Am. Chem. Soc., vol. 81, pp. 2537-2541, (1959).
Klingsberg et al., Pyridine and Its Derivatives, Part 3, pp. 516-522, Interscience Publishers, (1962).

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