Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-02-05
1998-04-28
Ambrose, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
558169, A61K 31685, C07F 910, C07F 940
Patent
active
057444595
ABSTRACT:
The compound of the present invention comprises a substituted lysophospholipid, which includes a C12 to C20 alkyl ether, a C12 to C20 thioether, or a substituted C3 to C6 heterocycle containing at least two ring heteroatoms, selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof; and also includes a choline group or a C4 to C7 heterocycle containing heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur and combinations thereof. The compounds of this invention possess antineoplastic and immunomodulatory characteristics.
REFERENCES:
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J. Gelas and S. Veyssieres-Rambaud, "Hydrogenolyse De 3,6,8-Trioxabicyclo D'Aluminium," Carbohydrate Research, 37:293-301 (1974).
H. Hayashi et al., "Activation of Guinea Pig Peritoneal Macrophages by Platelet Activating Factor (PAF) and its Agonists," J. Biochem., 97:1737-1745 (1985).
W. Berdel et al., "Lack of Correlation Between Cytotoxicity of Agonists and Antagonics of Platelet Activating Factor (Paf-acether) in Neoplastic Cells and Modulation of .sup.3 H-Par-acether Binding to Platelets from Humans in vitro," Anticancer Research, 7:1181-1187 (1987).
K. Meyer et al., "In Vitro Evaluation of Phosphocholine and Quaternary Ammonium Containing Lipids as Novel Anti-HIV Agents," J. Med. Chem. 34:1377-1383 (1991).
Duclos, Jr. Richard I.
Fournier Donna J.
Makriyannis Alexandros
Ambrose Michael G.
University of Connecticut
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