DNA encoding seryl tRNA synthetase from Staphylococcus aureus

Details DNA encoding seryl tRNA synthetase from Staphylococcus aureus DNA encoding seryl tRNA synthetase from Staphylococcus aureus

1997-01-17

1998-04-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057443386

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Ogasawara et al. (1994) Systematic Sequencing of the 180 Kilobase Region of the Bacillus subtilis Chromosome Containing the Replication Origin. DNA Research 1: 1-14.

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