Process for 5'-phosphorylation of nucleic acids

Details Process for 5'-phosphorylation of nucleic acids Process for 5'-phosphorylation of nucleic acids

1989-08-21

1991-08-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C08H 2100, C08H 2102, C08H 2104

Patent

active

050397966

ABSTRACT:
Compounds of the formula ##STR1## are phosphorylating reagents which react with acylatable hydrogen atoms with elimination of the amine HNR.sup.3 R.sup.4. The resulting compounds are oxidized to give the corresponding phosphate, thiophosphate or selenophosphate derivatives, and the radicals R.sup.1 and R.sup.2 are then split off by means of bases. The chemical nature of the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 accordingly depends on the requirements for these cleavage reactions.

REFERENCES:
patent: 3201435 (1965-08-01), Schulz
patent: 4321365 (1982-03-01), Wu et al.
patent: 4415732 (1983-11-01), Caruthers et al.
New England Biolabs Catalog, 1985-86, Beverly, Mass., see p. 20.
F. Himmelsbach et al., Tetrahedron Letters, vol. 23, 1982, pp. 4793-4796.
Chemical Abstract 97: 182538q.
Chemical Abstract 95: 168692n.
Chemical Abstract 87: 183904m.
European Search Report in prosecution of corresponding European appln.
Chemical Abstract, vol. 79, No. 53549y.
Chemical Abstract No. 101, No. 230935s.
Chemical Abstract vol. 78, No. 57700t.

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