Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1989-11-16
1991-08-13
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514425, A61K 3119
Patent
active
050397036
ABSTRACT:
A method for the treatment of inflammatory bowel disorders, together with a pharmaceutical composition comprising short chain fatty acids that is useful therein, is described in this invention. The administration of short chain fatty acids of about 2 to about 6 carbon-length to patients afflicated with inflammatory bowel disorders is shown to effectively alleviate the symptoms of the treated disorder.
REFERENCES:
W. E. W. Roediger, "The Colonic Epithelium in Ulcerative Colitis: An Energy-Deficiency Disease", The Lancet, Oct. 4, 1980, pp. 712-715.
Harig et al., "Treatment of Diversion Colitis with Short Chain Fatty Acid (SCFA) Irrigation", Abstracts of Papers, 88th Annual Meeting of the American Gastro-Enterological Association, May 1987, p. 1425.
Schilli et al., "Comparison of the Composition of Faecel Fluid in Crohn's Disease and Ulcerative Colitis", Gut. 1982, 23, 326-332.
Vernia et al., "Organic Anions and the Diarrhea of Inflammatory Bowel Disease" Digestive Diseases and Sciences, vol. 33, No. 11 (Nov. 88), pp. 1353-1358.
Vernia et al., "Fecal Lactate and Ulcerative Colitis", Gastroenterology, Dec. 88, vol. 95, No. 6, pp. 1564-1568.
Harig et al., "Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation", The New England Journal of Medicine, Jan. 5, 1989, vol. 320, No. 1, pp. 23-28.
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