Liquid purification or separation – With means to add treating material – Chromatography
Patent
1989-09-13
1991-08-13
Silverman, Stanley S.
Liquid purification or separation
With means to add treating material
Chromatography
73 611C, 364497, B01D 1508
Patent
active
050394096
ABSTRACT:
Chromatography apparatus capable of deriving optimum conditions for an analysis includes data processing means which comprises calculating means (20) to be supplied with initial conditions (24) entered by the chromatographer and which may be calculated from the results of an initial chromatogram, limits and requirements (25) relating to limiting values of parameters of the chromatograph and to the required selectivity and sensitivity of the analysis and which are entered by the chromatographer, and the detector time constant (23) which is selectable, within limits, by the chromatographer. The data processing means also includes a column data base (21) which contains data specifying the available separating columns and a detector data base (22) which contains data specifying the available detectors.
The optimization criteria are the minimum possible analysis time coupled with adequate peak separation and sensitivity. The optimum conditions are obtained by calculating maximum mobile phase flow rates which produce the required peak separation and sensitivity with each available separating column, detector, time constant combination and selecting that combination which allows the fastest analysis (26). The conditions may either be automatically set up or indicated to the chromatographer by means of a display unit, or a hard copy may be produced by a printer.
The parameters which limit the speed of analysis are indicated to the chromatographer to enable conditions to be relaxed, under the control of the chromatographer, if that is considered acceptable in order that a faster analysis may be achieved.
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Introduction to Modern Liquid Chromatography, Snyder & Kirkland, 2nd ed., Wiley & Sons (1979), p. 130.
Blaffert Thomas
Dunand Nicholas C.
Schoenmakers Petrus J.
Miller Paul R.
Nessler Cynthia L.
Silverman Stanley S.
U.S. Philips Corporation
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