Method and a kit containing means for the kinetic determination

Details Method and a kit containing means for the kinetic determination Method and a kit containing means for the kinetic determination

1989-04-05

1993-04-20

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

436 69, 530328, C12Q 156, G01N 3386, C07K 706

Patent

active

052042405

ABSTRACT:
A method for the detection and for the determination of blood coagulation factor XIII in plasma, as well as a kit containing means which can be used in this method, are described.
Used in this method are a fibrin-aggregation inhibitor, thrombin, a glutamine-containing peptide as substrate for factor XIII, an amine and a system for detecting ammonia which is formed.
The kit containing means which can be used in this method contains a fibrin-aggregation inhibitor and a glutamine-containing peptide, where appropriate in addition to other components necessary for the method.

REFERENCES:
patent: 5049506 (1991-09-01), Stuber
Fesus et al., "Synthetic Gutamine Poptides as Substrates for the Kinetic Determination of Blood Coagulation Factor XIII," Clin Chem 31, 2044-45 (1985).
Gorman et al., J. Biol. Chem. 259:9007-9010 (1984).
J. J. Gorman et al., J. Biol. Chem. 255, No. 2, 419-427 (1980).
J. J. Gorman and J. E. Folk, "Peptides: Structure and Function, Proceedings of the American Peptide Symposium, 9th Toronto" pp. 363-366 (1985) Editors Deber et al.
Muszbek et al., "Kinetic Determination of Blood Coagulation Factor XIII in Plasma," Clinical Chemistry, vol. 31, No. 1, pp. 35-40 (1985).
Miraglia et al., "Measurement of Blood Coagulation Factor XIIIa Formation in Plasma Containing Glycyl-L-prolyl-L-arginyl-L-Proline," Analytical Biochemistry 144, pp. 165-171 (1985).

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