Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagn

Details Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagn Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagn

1989-04-14

1993-04-20

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 424 86, 424 858, 530324, 530328, 530329, 530350, 514 13, 514 14, 514 15, 514 17, A61K 3912, A61K 3702

Patent

active

052040968

ABSTRACT:
A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen or hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

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