Small molecule mimetics of erythropoietin

Details Small molecule mimetics of erythropoietin Small molecule mimetics of erythropoietin

1996-04-26

1998-11-10

Trammell, James P.

Boots, shoes, and leggings

364578, G06F 1900, G06F15900

Patent

active

058353828

ABSTRACT:
The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

REFERENCES:
patent: 5265030 (1993-11-01), Skolnick et al.
patent: 5331573 (1994-07-01), Balaji et al.
patent: 5555366 (1996-09-01), Teig et al.
patent: 5557535 (1996-09-01), Srinivasan et al.
Livnah et al., "Functional Mimicry of a Protein Hormone by a Peptide Agonist", Science, 26 Jul. 1996, vol. 273, No. 274, pp. 464-471.
McCarthy, "Small Peptide Designed that can Mimic Erythropoietin", Lancet, Aug. 1996, vol. 348, No. 24, p. 395.
Wrighton et al., "Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin" Science 273:458-463, Jul. 1996.

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