Piperazinyl-substituted pyridine and imidazole anti-arrhythmic a

Details Piperazinyl-substituted pyridine and imidazole anti-arrhythmic a Piperazinyl-substituted pyridine and imidazole anti-arrhythmic a

1987-02-02

1989-02-21

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544360, 544370, A61K 31495, C07D40104, C07D40304

Patent

active

048065366

ABSTRACT:
A series of novel 4-substituted piperazinyl-pyridine and 4-substituted piperazinyl-imidazole compounds have been prepared, including their pharmaceutically acceptable salts, wherein the 4-substituent is a lower phenylalkyl group or a derivative thereof further substituted on the phenyl moiety by a sulphamoyl or sulphonylamino group or by a nitro, amino or acetamido group. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrythmias. The most preferred member compound of the series is N-{4-[1-hydroxy-2-(4-[4-pyridinyl]-1-piperazinyl)ethyl]phenyl} methanesulphonamide. Methods for preparing all these compounds from known starting materials are provided.

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