Anti-inflammatory 1-phenyl-2,3-butadien-1-ols, methods of use an

Details Anti-inflammatory 1-phenyl-2,3-butadien-1-ols, methods of use an Anti-inflammatory 1-phenyl-2,3-butadien-1-ols, methods of use an

1975-09-18

1977-06-28

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602477Z, 260268PH, 260618R, 424250, 424343, 42424857, 42424858, C07C 3306

Patent

active

040325806

ABSTRACT:
Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.

REFERENCES:
patent: 2930817 (1960-03-01), Fert et al.
patent: 3435075 (1969-03-01), Glamkowski et al.
patent: 3629314 (1971-12-01), Kulka
patent: 3723091 (1973-03-01), Allais et al.
patent: 3806551 (1974-04-01), Blume
patent: 3888933 (1975-06-01), Anderson
patent: 3891716 (1975-06-01), Anderson
Bardone-Gaudemar, "Comp. Rend. (Pans)," Tome 245, pp. 324-326, (1957).
Bertrand et al., "Comp. Rend. (Pans)," Tome 255, pp. 1305--1307, (1952).

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