Hybrid cell line for producing monoclonal antibody to a human pr

Details Hybrid cell line for producing monoclonal antibody to a human pr Hybrid cell line for producing monoclonal antibody to a human pr

1984-09-04

1989-02-21

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Lymphokine

4351722, 43524026, 43524027, 436548, 530387, 530808, 530809, 935104, 935105, A61K 3900, G01N 3353, C12N 1500, C12N 500

Patent

active

048063495

ABSTRACT:
Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

REFERENCES:
patent: 4364935 (1982-12-01), Kung et al.
Reinherz, E. L. et al., PNAS, 77, No. 3, 1588-1592 (1980).
Schlossman, S. et al., Proc. Natl. Acad. Sci. 73, No. 4; 1288-1292 (1976).
Reinherz, E. L. et al., J. Clin. Invest. 64: 392-397 (1979).
McMichael, J. J. et al., Eur. J. Immunol. 9: 205-210 (1979).
Hauptman, S. P. et al., J. Immunol. 122, No. 3: 1035-1040 (1979).
Trucco, M. M. et al., in "Current Topics in Microbiology and Immunolgy vol. 81" (Arber et al. eds) Springer-Verlag, publisher, Berlin (1978).

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