Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com

Details Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com Cephalosporin phosphonic acid, sulfonic acid and sulfonamide com

1973-11-08

1977-06-28

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, 260243R, C07D50138, C07D50126, A61K 31545

Patent

active

040325210

ABSTRACT:
Novel antibiotics of the formula: ##STR1## and its salts, esters and amides wherein R is acyl; B is H, OCH.sub.3, CH.sub.3 or SR" wherein R" is lower alkyl; A is hydrogen, hydroxy, or an organic group; and, Y is a radical of the formula PO(OH).sub.2 ; PO(OH) (OR") wherein R" is loweralkyl; SO.sub.2 (OH); or SO.sub.2 NH.sub.2.
The products are prepared by a multi-step process starting with an .alpha.-aminophosphonoacetate and terminating in the acylation of the 7-amino compound, and, if desired, removing the ester blocking group. The products are useful antibiotics.

REFERENCES:
patent: 3801567 (1974-04-01), Heusler et al.
patent: 3856785 (1974-12-01), Breuer
patent: 3966719 (1976-06-01), Barth

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