Process for the preparation of 3-hydroxymethyl cephalosporins

Details Process for the preparation of 3-hydroxymethyl cephalosporins Process for the preparation of 3-hydroxymethyl cephalosporins

1977-10-07

1979-01-02

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 30, 424246, 544 18, C07D50104

Patent

active

041328493

ABSTRACT:
A process for the preparation of a 3-hydroxymethyl cephalosporin compound which comprises selectively hydrolyzing a 3-formyloxymethyl cephalosporin compound under acidic conditions in the presence of a protic solvent whereby a 3-hydroxymethyl cephalosporin is produced.

REFERENCES:
patent: 3202656 (1965-08-01), Abraham et al.
patent: 3532694 (1970-10-01), Somerfield et al.
patent: 4038275 (1977-07-01), Koppel et al.

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