Conversion of pyridinoline to deoxypyridinoline

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546347, C07D21365, C07D21374

Patent

active

058346104

ABSTRACT:
The present invention involves the synthetic conversion of pyridinoline (PYD) to deoxypyridinoline (DPD) via an intermediate ester which is subsequently cleaved. The transformation of PYD into a xanthate-type ester intermediate facilitates the subsequent removal of the substituted hydroxyl functionality thus providing the desired DPD. The method provides a new chemical pathway for the preparation of DPD, resulting in significantly increased yields as compared to traditional methods of product isolation.

REFERENCES:
patent: 5300434 (1994-04-01), Eyre
patent: 5350855 (1994-09-01), Daniloff et al.
patent: 5455179 (1995-10-01), Eyre
patent: 5502197 (1996-03-01), Daniloff et al.
patent: 5527715 (1996-06-01), Kung et al.

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