Substituted dibenz (A F)azulenes and methods of preparation

Details Substituted dibenz (A F)azulenes and methods of preparation Substituted dibenz (A F)azulenes and methods of preparation

1996-08-05

1998-11-10

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Hydrocarbon doai

514381, 514546, 514625, 514656, 514718, 514717, 514721, 514729, 514753, 514680, 548251, 560129, 560190, 562 8, 564221, 564222, 564426, 568326, 568632, 568633, 568808, 574123, 574183, 585 26, 585 27, A61K 31015, A61K 3109, C07C 1366

Patent

active

058345213

ABSTRACT:
Tetracyclic compounds having the following structure are described: ##STR1## wherein R.sub.1 -R.sub.10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.

REFERENCES:
Koppes et al, Recl. Trav. Chim. Days--Bas, 549-62, 1988.
Korth et al, J. Am. Chem. Soc., 2767-2777, 1994.
Sasaki et al, Chem. Pharm. Bull., 2868-2878, 1983.

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