Ketone derivatives

Details Ketone derivatives Ketone derivatives

1997-02-06

1998-11-10

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514315, 514372, 514378, 549 13, 549 21, 549 58, 549 76, 549357, 549427, 549467, 549496, 544399, 546334, 546246, 548214, 548569, 548225, 548243, 568 30, A61K 3134, C07D30702, C07D33560, C07D26304

Patent

active

058345086

ABSTRACT:
A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.

REFERENCES:
patent: 5055451 (1991-10-01), Krantz et al.
Krantz et al., Biochemistry, 30(19), 4678-4687 (1991).
Smith et al., J. Am. Chem. Soc., 110(13), 4429-4431 (1988).
Zumbrunn et al., Biochem. J., 256, 989-994 (1988).
Shaw et al., J. Biol. Chem., 263(6), 2768-2772 (1988).
Rauber et al., Biochem. J., 250, 871-876 (1988).
WPI Acc. No. 92-034226/05 (EP 468469) (Jul. 27, 1990).
WPI Acc. No. 92-065587/09 (DD 294176) (May 11, 1990).
Robinson et al., Chemical Abstracts, 117:22302m (1992).

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