N-heterocyclic piperazinyl and H-heterocyclic piperazinonyl inhi

Details N-heterocyclic piperazinyl and H-heterocyclic piperazinonyl inhi N-heterocyclic piperazinyl and H-heterocyclic piperazinonyl inhi

1997-03-27

1999-01-12

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544359, 544360, 544361, 544370, 544386, 544388, 544391, A61K 31495, C07D40304

Patent

active

058590153

ABSTRACT:
The present invention is directed to compounds of the formula A which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras: ##STR1## The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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