Transcription factor and uses therefor

Details Transcription factor and uses therefor Transcription factor and uses therefor

1994-02-23

1999-01-12

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530358, 530311, A61K 3800, A61K 3816, A61K 3831

Patent

active

058589732

ABSTRACT:
The invention features a novel recombinant polypeptide that transactivates the somatostatin promoter, the polypeptide being present in pancreatic duct cells and not present in pancreatic .alpha.-cells, the polypeptide being encoded by a gene which encodes a protein on the order of 31 kd.

REFERENCES:
patent: 5240911 (1993-08-01), Totsuka et al.
C.P. Miller et al., Abstract: "IDX-1: A New Homeodomain Transcription Factor Expressed in Rat Islets and Duodenum", 75th Annual Meeting of The Endocrine Society, Las Vegas, Nevada, Jun. 1993.
Ohlsson et al., "IPF1, a Homeodomain Containing Transactivator of the Insulin Gene", The EMBO Journal 12:4251-4259, No. 11, Nov. 1993.
Leonard et al., "Characteriztion of Somatostatin Transactivation Factor-1, a Novel Homeobox Factor that Stimulates Somatosttin Expression in Pancreatic Islet Cells", Molecular Endocrinology 7:1275-1283, Oct. 1993.
C.P. Miller et al., "IDX-1: A New Homeodomain Transcription Factor Expressed in Rat Pancreatic Islets and Duodenum that Transactivated the Somatostatin Gene", The EMBO Journal 13, No. 4, 1994.
Leonard et al., "Characterization of STF-1, A Novel Homeodomain Factor Which Cooperates With Creb to Stimulate Somatostatin Expression in Pancreatic Islet Cells", The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, Jun. 1993.

Affiliated with

Also associated with

Rating

Transcription factor and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transcription factor and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcription factor and uses therefor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1515981