Muramyldipeptide derivatives and influenza vaccine comprising th

Details Muramyldipeptide derivatives and influenza vaccine comprising th Muramyldipeptide derivatives and influenza vaccine comprising th

1991-10-28

1994-03-08

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 514 8, A61K 3912, A61K 3700, A61K 3710, C07K 900

Patent

active

052925064

ABSTRACT:
Novel muramyldipeptide derivatives such as [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-D-glutamamide and [6-0-(2-tetradecylhexadecanoyl)-N-acetylmuramoyl]-L-alanyl-N -methyl-D-glutamamide are provided. The muramyldipeptide derivatives are excellent compound as an adjuvant or a constituting component of virosome vaccine. An influenza vaccine comprises a complex of the muramyldipeptide derivative and an influenza virus antigen. The influenza vaccine has excellent antibody-producing capacity and safety.

REFERENCES:
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Chemical Abstracts 182620q.
Furuya et al., "Enhancement of Immunoglobulin G Responses in Mice Against Hepatitis B Virus Surface Antigen, Influenza Virus Hemagglutinin Vaccine, and Tetanus Toxoid by 6-O-Acylated Muramyl Dipeptides," Infection and Immunity, vol. 57, No. 6, Jun. 1989, pp. 1839-1844.
Nerome et al., "Development of a new type of influenza subunit vaccine made by muramyldipeptide-liposome: enhancement of humoral and cellular immune responses," Vaccine, vol. 8, Oct. 1990, pp. 503-509.

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