Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1992-02-25
1994-03-08
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Dentifrices
424 53, A61K 722
Patent
active
052925005
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to a toothpaste in the form of a dispersion of water-insoluble polishing agents in an aqueous carrier which contains an antimicrobial biguanide compound as plaque-inhibiting component and of which the other components are selected in regard to type and quantity so that optimal inhibition of plaque formation is obtained despite a relatively low dosage of the antimicrobial biguanide compounds.
Statement of Related Art
It has long been known that antimicrobial biguanide compounds are effective in inhibiting the formation of plaque. However, their effect in this regard is greatly reduced or totally eliminated by many components typically present in toothpastes, more particularly by certain polishing agents, by many binders or consistency regulators, surfactants and even by sweeteners.
Accordingly, there has been no shortage of attempts to find components which do not impair the effect of the antimicrobial biguanides. Thus, according to DE-OS 21 58 149 for example, .alpha.-aluminium oxide trihydrate in a certain particle size is used as polishing agent. On the other hand, according to DE-OS 34 44 958, certain surfactants can enhance the effect of an antimicrobial biguanide. It has now been found that even this effect is greatly reduced by certain toothpaste components, for example by anionic binders or consistency regulators, anionic sweeteners and certain solubilizers which are necessary for solubilizing any flavoring oils present. A toothpaste which combines high biguanide availability with a satisfactory plaque-inhibiting effect, even despite a low dosage of the antimicrobial biguanide compounds is not mentioned in the prior art. The object of the present invention was to provide such a toothpaste.
SUMMARY OF THE INVENTION
The present invention relates to a toothpaste in the form of a dispersion containing flavoring oils and sweeteners, oil as surfactants and
DESCRIPTION OF PREFERRED EMBODIMENTS
.alpha.-Aluminum oxide trihydrate, Al (OH).sub.3, is a known polishing agent for toothpastes. A ground quality in which the particles are predominantly (at least 98%) smaller than 50.mu. in size with an average of approximately 1 to 10.mu. is particularly suitable.
The toothpaste according to the invention preferably contains a mixture of .alpha.-aluminium oxide trihydrate (A) and a weakly calcined alumina (B) in a ratio by weight of A to B of 100 : (1-15) in a quantity of 30 to 604 by weight, because a particlularly good polishing effect with no roughening secondary effect is obtained in this way.
The weakly calcined alumina preferably has a gamma-aluminium oxide (.gamma.-Al.sub.2 O.sub.3) content of approximately 20% by weight and an alpha-aluminium oxide (.alpha.-Al.sub.2 O.sub.3) content of approximately 80% by weight, an agglomerate size below 20.mu., an average primary crystal size of 0.5 to 1.5.mu. and an apparent density of 500 to 600 g/l.
Suitable weakly calcined aluminas are obtained by calcination from aluminium hydroxide. Aluminium hydroxide is converted by calcination into .alpha.-Al.sub.2 O.sub.3 which is thermodynamically stable at temperatures above 1,200.degree. C. The thermodynamically unstable forms of Al.sub.2 O.sub.3 occurring at temperatures between 400.degree. and 1,000.degree. C. are known as gamma forms (cf. Ullmann, Encyclopadie der technischen Chemie, 4th Edition (1974), Vol. 7, page 298). The degree of calcination, i.e. the conversion into the thermodynamically stable .alpha.-Al.sub.2 O.sub.3, can be adjusted as required through the calcination temperature and the calcination time. An alumina having an .gamma.-Al.sub.2 O.sub.3 content which is lower, the higher the calcination temperature and the longer the calcination time, is obtained by weak calcination. Weakly calcined aluminas are distinguished from pure .alpha.-Al.sub.2 O.sub.3 by lower agglomerate hardness, a larger specific surface and larger pore volumes.
Aluminium oxide polishes are commercially available in various degrees of calcination, fine
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Foerg Franz
Lehmann Rudolf
Ploeger Walter
Wuelknitz Peter
Griffin Ronald W.
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Wisdom, Jr. Norvell E.
Wood John D.
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