Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-04-29
1999-01-12
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435325, 4352523, 43525233, 435419, 4353201, 536 232, 536 2431, C12N 1509, C12N 914, C07K 14435
Patent
active
058587560
ABSTRACT:
The present invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing NHLP and for treating or preventing disorders associated with expression of NHLP.
REFERENCES:
Sugimoto et al "Purification, cDNA cloning, and regulation of lysophospholipase from rat liver" J. Biol. Chem. (Mar. 29, 1996) vol. 271, No. 13, pp. 7705-7711.
Genbank Accession D63885 "Rat liver mRNA for lysophospholipase, complete cds." Submitted by H. Sugimoto, May 9, 1996.
Genbank Accession R12332 "yf55e02.r1 Homo sapienscDNA clone 25773 (5')" Submitted by RK Wilson, Apr. 12, 1995.
dbEST record ID "yf55e02.r1 Homo sapienscDNA clone 25773 (5')" Record corresponds to Genbank Accession R12332 submitted by RK Wilson, May 9, 1996.
Genbank Accession R59445 "yh17f05.r1 Homo sapienscDNA clone 37830 (5')" Submitted by RK Wilson, May 24, 1995.
dbEST record ID "yh17f05.r1 Homo sapienscDNA clone 37830 (5')" Record corresponds to Genbank Accession R59445 submitted by RK Wilson, May 9, 1996.
Boguski et al. "Gene discovery in dbEST" Science (Sep. 30, 1994) vol. 265, pp. 1993-1994.
Yan et al. "Molecular cloning and functional expression of humandeoxyhypusine synthase cDNA based on expressed sequence tag information" Biochemical Journal (Apr. 15, 1996) vol. 315, pp. 429-434.
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Garsetti et al. "Butyric acid-induced differentiation of HL-60 cells increases the expression of a single lysophospholipase" Biochemical Journal (Dec. 1, 1992) vol. 288, p. 831-837.
Weltzien "Cytolytic and membrane-perturbing properties oflysophosphatidylcholine" Biochimica et Biophysica Acta (Aug. 1, 1979) vol. 559, pp. 259-287.
Wang A, et al Regiospecificity and catalytic triad oflysophospholipase I. J Biol Chem. 1997 Aug. 29; 272(35): 22030-22036.
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She HS, et al. The substrate specificities of four differentlysophospholipases as determined by a novel fluorescence assay. Biochem J. 1994 Feb. 15; 298(Pt 1): 23-29.
Taylor JK, et al. Comparison of intestinalphospholipase A/lysophospholipase and sucrase-isomaltase genes suggest a common structure forenterocyte-specific promoters. DNA Cell Biol. 1997 Dec. 1; 16(12):1419-1428.
Sugimoto, H. et al., "Purification, cDNA Cloning, and Regulation of Lysophospholipase from Rat Liver." J.Biol.Chem. (1996) 271(13):7705-7711.
Selle, H. et al., "Glycerophosphocholine release in human erythrocytes. 1H spin-echo and 31P-NMR evidence for lysophospholipase." Eur.J.Biochem. (1993) 212(2):411-416.
Endresen, M.J. et al., "Increased lipolytic activity of sera from pre-eclamptic women due to the presence of a lysophospholipase." Scand.J.Clin.Lab Invest. (1993) 53(7):733-739.
Anderson, R. et al., "Alpha-tocopherol prevents cyclosporin A-mediated activation of phospholipase A2 and inhibition of Na+, K(+)-adenosine triphosphatase activity in cultured hamster renal tubular cells." Toxicol.Appl.Pharmacol. (1994) 125(2):176-183.
Sugimoto, H. et al. (GI 1552244), GenBank Sequence Database (Accession D63885), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No Year Provide.
Sugimoto, H. et al. (GI 1552243), GenBank Sequence Database (Accession D63885), National Cancer for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. No Year Provide.
Sugimoto, H. et al. "Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver." J.Biol.Chem. (1994) 269(8):6252-6258.
Hillman Jennifer L.
Murry Lynn E.
Shah Purvi
Billings Lucy J.
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mayhew Bradley S.
Mohan-Peterson Sheela
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