Polynucleotides encoding human ATP binding-cassette transport pr

Details Polynucleotides encoding human ATP binding-cassette transport pr Polynucleotides encoding human ATP binding-cassette transport pr

1997-07-17

1999-01-12

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 4353201, 4352523, 435325, 536 231, C12P 2106, C12Q 168, C12N 1500, C07H 1700

Patent

active

058587195

ABSTRACT:
The invention provides a human ATP-binding cassette transport protein (ABCtxH) and polynucleotides which identify and encode ABCtxH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ABCtxH.

REFERENCES:
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Buchler, M. et al., "cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats", J. Biol. Chem., 271:15091-15098 (1996).
Michaelis, S., "STE6, the yeast a-factor transporter", Semin. Cell Biol., 4: 17-27 (1993).
Savary, S. et al., "Isolation and Chromosomal mapping of a Novel ATP-Binding Cassette Transporter Conserved in Mouse and Human", Genomics, 41: 275-278 (1997) (GI 1167982).
Savary, S. et al., (Direct Submission), GenBank Sequence Database (Accession 1167982), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1167982).
Savary, S. et al., (Direct Submission), GenBank Sequence Database (Accession U43892), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1167982).
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Leighton, J. et al., (Direct Submission), GenBank Sequence Database (Accession X82612), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 575393).
Leighton, J. et al., "An ABC transporter in the mitrochondrial inner membrane is required for normal growth of yeast", EMBO J., 14: 188-195 (1995) (GI 575393).

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