Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-06-11
1999-01-12
Spector, Lorraine
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 530350, 435 711, 435325, C12N 1500
Patent
active
058587179
ABSTRACT:
The invention provides a human formin binding protein (FBPhu) and polynucleotides which identify and encode FBPhu. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of FBPhu.
REFERENCES:
Adams et al., GenBank accession U77625 (g1684823), Nov. 24, 1996.
Hillier et al., GenBank accession W40133 (g1324273), Oct. 11, 1996.
Woychik, R.P. et al., "`Formins`: proteins deduced from the alternative transcripts of the limb deformity gene", Nature, 346: 850-853 (1990).
Ren, R. et al., "Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site", Science, 259: 1157-1161 (1993).
Chan, D.C. et al., "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains", EMBO J., 15: 1045-1054 (1996) (GI 1255023; GI 1255025).
Bork, P. et al., "The WW domain: a signalling site in dystrophin?", Trends Biochem. Sci., 19: 531-533 (1994).
Uetz, P. et al., "Molecular Interaction between Limb Deformity Proteins (Formins) and Src Family Kinases", J. Biol. Chem., 271: 33525-33530 (1996).
Adams, L.D. et al., GenBank Sequence Database (Accession 1684826), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1684826).
Groden, J. et al., "Response of Colon Cancer Cell Lines to the Introduction of APC, a Colon-specific Tumor Suppressor Gene", Cancer Res., 55: 1531-1539 (1995).
Chan, D.C. et al., GenBank Sequence Database (Accession 1255023), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1255023).
Chan, D.C. et al., GenBank Sequence Database (Accession U40746), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1255022).
Adams, L.D. et al., GenBank Sequence Database (Accession 1684826), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1684826).
Adams, L.D. et al., GenBank Sequence Database (Accession U77625), National Center for Biotechnology Information, National Libray of Medicne, Bethesda, Maryland, 20894 (GI 1684823; GI 1684825).
Chan, D.C. et al., GenBank Sequence Database (Accession 1255025), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1255025).
Chan, D.C. et al., GenBank Sequence Database (Accession U40747), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1255024).
Hillman Jennifer L.
Lal Preeti
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Lazar-Wesley Eliane
Price Leanne C.
Spector Lorraine
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