Fibronectin binding protein B compounds

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4353201, 4352523, 536 231, 530350, C12P 2106, C07H 2102, C07H 2104

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active

058587098

ABSTRACT:
Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.

REFERENCES:
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Ryden, et al., "Detection of Staphylococcus Aureus Infection by Enzyme-Linked Immunosorbent Assay and Immunoblotting, Using High Molecular Weight Staphylococcal Proteins", FEMS Microbiol. Immunol., vol. 2, No. 2: pp. 65-73, (1990).

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