Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-10-03
1999-01-12
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4352523, 4353201, 536 235, C12N 1512, C12N 1563, C12N 1585
Patent
active
058587012
ABSTRACT:
A substantially pure nucleic acid comprising a sequence encoding an IRS-2 polypeptide, a substantially pure preparation of an IRS-2 polypeptide, and related methods.
REFERENCES:
patent: 5260200 (1993-11-01), Kahn et al.
Rudinger, In "Peptide Hormones" (Jun. 1976) ed. J.A. Parsons, University Park Press, Baltimore, pp. 1-7.
Keegan, A.D. et al, (1994) "An IL-4 Receptor Region Containing an Insulin Receptor Motif is Important for IL-4-mediated IRS-1 Phosphorylation and Cell Growth", Cell, vol. 76, pp. 811-820.
Araki, E., et al, (1994) "Cloning of the Mouse Insulin Receptor Substrate-1 (IRS-1) Gene and Complete Sequence of Mouse IRS-1", Biochim. Biophys. Acta, vol. 1221, pp. 353-356.
Araki, E. et al, (1994) "Alternative Pathway of Insulin Signaling in Mice with Targeted Disruption of the IRS-1 Gene", Nature, vol. 372, No. 6572, pp. 186-190.
Myers, M.G., et al, (1994) "The IRS-1 signaling system", Trends in Biochem Sci., vol. 19, pp. 289-293.
Wang, L.M., et al, (1993) "IRS-1: Essential for Insulin and IL-4-stimulated Mitogenesis in Hematopoietic Cells", Science, vol. 261, pp. 1591-1594.
Taniguchi, T and Minami, Y., (1993) "The IL-2/II-2 Receptor System: A Current Overview", Cell, vol. 73, pp. 5-8.
Koettnitz, K. and Kalthoff, F.S. (1993) "Human Interleukin-4 Receptor Signaling Requires Sequences Contained Within Two Cytoplasmic Regions", Eur. J. Immunol., vol. 23, pp. 988-991.
Wang, L.M., et al, (1993) "Common Elements in IL-4 and Insulin Signaling Pathways in Factor Dependent Hematopoietic Cells", Proceedings of the National Academy of Sciences, vol. 90, pp. 4032-4036.
Araki, E., et al, (1993) "Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene and Chromosomal Localization", Diabetes, vol. 42, pp. 1041-1054.
Musacchio, A., et al, (1993) "The PH Domain: A Common Piece in the Structural Patchwork of Signaling Proteins", Trends in Biochem. Sci., vol. 18, pp. 343-348.
Myers, M.G. and White, M.F., et al, (1993) "The New Elements of Insulin Signaling Insulin Receptor Substrate-1 and Proteins with SH2 Domains", Diabetes, vol. 42, pp. 643-650.
Lee, C.H., et al, (1993) "Nck Associates with the SH2 Domain Docking Protein IRS-1 in Insulin Stimulated Cells", Proceedings of the National Academy of Sciences, vol. 90, pp. 11713-11717.
Sun, X J., et al, (1993) "Pleiotropic Insulin Signals Are Engaged by Multisite Phosphorylation of IRS-1", Molecular and Cellular Biology, vol. 13, No. 12, pp. 7418-7428.
Wang, L.M., et al, (1992) "IL-4 Activates a Distinct Signal Transduction cascade from IL-3 in Factor Dependent Myeloid Cells", The EMBO Journal, vol. 11, pp. 4899-4908.
Harada, N., et al, (1992) "Identification of an Essential Region for Growth Signal Transduction in the Cytoplasmic domain of the Human Interleukin-4 Receptor", Journal of Biological Chemistry, vol. 267, No. 32, pp. 22752-22758.
Sun, X J., et al, (1992) "Expression and Function of IRS-1 in Insulin Signal Transmission", Journal of Biological Chemistry, vol. 267, No. 31, pp. 22662-22672.
Backer, J.M., et al, (1992) "The Phosphatidylinositol 3'-Kinase is Activated by Association with IRS-1 During Insulin Stimulation", The EMBO Journal, vol. 11, pp. 3469-3479.
Myers, M.G., et al, (1992) "IRS-1 Activates Phosphatidylinositol 3'-Kinase by Associating with src Homology 2 Domains of p85", Proceedings of the National Academy of Sciences, vol. 89, pp. 10350-10354.
Pawson, T., et al, (1992) "SH2 and SH3 Domains From Structure to Function", Cell, vol. 71, pp. 359-362.
Miralpeix, M., et al, (1992) "Insulin Stimulates Tyrosine Phosphorylation of Multiple High Molecular Weight Substrates in Fao Hepatoma Cells", Biochemistry, vol. 31, No. 37, pp. 9031-9039.
Sun, X J., et al, (1991) "Structure of the Insulin Receptor Substrate IRS-1 Defines a Unique Signal Transduction Protein", Nature, vol. 352, pp. 73-77.
Paul, W.E., (1991) "Interleukin-4: A Prototypic Immunoregulatory Lymphokine", Blood, vol. 77, No. 9, pp. 1859-1870.
Koch, C.A., et al, (1991) "SH2 and SH3 Domains Elements that Control Interactions of Cytoplasmic Signaling Proteins", Science, vol. 252, pp. 668-674.
Idzerda, R.L., et al, (1990) "Human Interleukin 4 Receptor Confers Biological Responsiveness and Defines a Novel Receptor Superfamily", J. Exp Med., vol . 171, pp. 861-873.
Cosman, D., et al., (1990) "A New Cytokine Receptor Superfamily", Trends in Biochem Sci., vol. 15, pp. 256-270.
Ferris, D K., et al, (1989) "Comparative Analysis of IL-2 and IL-3 Induced Tyrosine Phosphorylation", Lymphokine Research, vol. 8, No. 3, pp. 215-224.
Moria, A.O., et al, (1988) "Hematopoietic Growth Factors Activate the tyrosine phosphorylation of Distinct Sets of Proteins in Interleukin-3-dependent Murine Cell Lines", Mol. Cell Biol., vol. 88, No. 5, pp. 2214-2218.
Sitkovsky, M V., and Paul, W E., (1988) "Global or direct exocytosis?", Nature, vol. 332, pp. 306-307.
Pestka, S, and Langer, J A, (1987) "Interferons and their actions", Biochem., vol. 56, pp. 727-777.
White, M.F., et al, (1985) "Insulin rapidly stimulates tyrosine phosphorylation of a M.sub.r -185,000 protein in intact cells", Nature, vol. 318, pp. 183-186.
White et al, "The Insulin Signalling System" J Biological Chemistry, vol. 269 1-4 (1994).
Pierce Jacalyn H.
Sun Xiao Jian
White Morris F.
Hayes Robert C.
Hutzell Paula K.
Joslin Diabetes Center, Inc.
Myers, Esq. Louis
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