Capillary array electrophoresis system

Details Capillary array electrophoresis system Capillary array electrophoresis system

1996-09-23

1998-11-10

Warden, Robert J.

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

204452, G01N 2726, G01N 17447

Patent

active

058338276

ABSTRACT:
The capillary array electrophoresis system of the present invention comprises a plurality of capillaries whose inside is filled with migration medium and at least parts of which are aligned in a plane, a means for making lasers substantially simultaneously irradiate transparent parts of the plurality of capillaries along the direction of alignment of the plurality of capillaries so as to excite fluorephore labels of migrated and separated samples, a fluorescence detection means for detecting fluorescence radiating from the fluorephore labels, from a direction crossing the direction of the alignment, the transparent parts of the plurality of capillaries are surrounded by a transparent gas, the cross section of the capillary of the transparent part is a circle and the ratio of the outside diameter to the inside diameter of the capillary ranges from 1 to 7.

REFERENCES:
patent: 5312535 (1994-05-01), Waska et al.
patent: 5582705 (1996-12-01), Yeung et al.
Analytical Chemistry, 1990, May vol. 62, "High-Speed Separations of DNA Sequencing Reactions by Capillary Electrophoresis", H. Drossman et al, pp. 900-903.
Nature, vol. 359, Sep. 10, 1992, "Capillary array electrophoresis: an approach to high-speed, high-throughput DNA sequencing", Mathies et al, pp. 167-169.
Nature, vol. 361, Feb. 11, 1993, "Multiple-sheathflow capillary array DNA analyzer", H. Kambara et al, pp. 565-566.
Analytical Chemistry, vol. 65, No. 7, Apr. 1, 1993, "Multiplexed Fluorescence Detector for Capillary Electrophoresis Using Axial Optical Fiber Illumination", J. Taylor et al, pp. 956-960.
Analytical Chemistry, May 1994, vol. 66, Simultaneous Monitoring of DNA Fragments SEpaated by Elctrophoresis in a Multiplexed Array of 100 Capillaries, K. Ueno et al, pp. 1424-1431.
Applied Spectroscopy, vol. 49, No. 5, 1995, "Optimization of Excitation and Detection Geometry for Multiplexed Capillary Array Electrophoresis of DNA Fragments", Xiandan Lu et al, pp. 605-609.
Electrophoresis, No month available 1992, vol. 13, "Formamide modified polyacrylamide gels for DNA sequencing by capillary gel electrophoresis", M. Rocheleau et al, pp. 484-486.

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