Purified AIDS-associated virus

Details Purified AIDS-associated virus Purified AIDS-associated virus

1995-06-07

1999-01-12

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4241884, 530350, 530395, 435 5, 435 71, A61K 3921, A61K 3912, C12Q 170, G01N 3353

Patent

active

058583742

ABSTRACT:
A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg.sup.++ --dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.

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