NIMA interacting proteins

Details NIMA interacting proteins NIMA interacting proteins

1998-04-24

1999-09-14

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530324, C07K 1400

Patent

active

059524677

ABSTRACT:
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

REFERENCES:
Morris et al. (1989) BioEssays 10/6:196-201, 1989.
Chong et al., "A Human Telomeric Protein," Science, vol. 270, Dec. 8, 1995, pp. 1663-1667.
Lu et al., "Expression of the noncatalytic domain of the NIMA kinase causes of G2 arrest in Aspergillus nidulans", EMBO Journal, 1994, vol. 13, No. 9, pp. 2103-2113.
Osmani et al., "Mitotic Induction and Maintance by Overexpression of a GS-Specific Gene that Encodes a Potential Protein Kinase", Cell, Apr. 22, 1988, vol. 53, pp. 237-244.
Lu et al., "Evidence for a NIMA-like Mitotic Pathway in Vertebrate Cells", Cell, May 5, 1995, vol. 81, pp. 413-424.
O'Connell et al, "Premature chromatin condensation upon accumulation of NIMA", EMBO Journal, 1994, vol. 13, No. 20, pp. 4926-4937.
Hillier et al., (1991) Accession No. H41102, EST-STS database.
Hillier et al., (1995) Accession No. T82035, EST-STS database.

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