Adamantyl-substituted retinoids and pharmaceutical/cosmetic comp

Details Adamantyl-substituted retinoids and pharmaceutical/cosmetic comp Adamantyl-substituted retinoids and pharmaceutical/cosmetic comp

1996-05-03

1999-09-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562466, 562469, 562473, A61K 3119, C07C 6206

Patent

active

059523824

ABSTRACT:
Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ailments manifesting an overregulation of RAR receptors and/or a hypervitaminosis A.

REFERENCES:
patent: 5124473 (1992-06-01), Shroot et al.
patent: 5574036 (1996-11-01), Bernardon et al.
J. Pharm. Belg., 1994, 221-5, Shroot et al.
Biochem. Biophys. Res. Commun, 1992, 977-83, Bernard et al.
Lee et al, Proc. Natl. Acad. Sci., USA, 91:5632-5636 (1994).
Lee et al., J. Biol. Chem., 271(20):11897-11903 (1996).
Yoshimura et al, J. Med. Chem., 38:3163-3173 (1995).

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